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Anti-p70 S6 Kinase

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货号：07-402

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R IP, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-402
Replaces 04-391
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-p70 S6 Kinase Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-p70 S6 Kinase Antibody is an antibody against p70 S6 Kinase for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen peptide corresponding to amino acids 26-43 of rat p70 S6 Kinase, with an N-terminal cysteine
Host Rabbit
Specificity p70 S6 kinase
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Gene Symbol
  • RPS6KB1
  • p70-alpha
  • p70S6k
  • p70-S6K
  • p70
  • S6K
  • S6Kalpha)
  • P70S6K
  • STK14A
  • S6K1
  • p70(S6K)-alpha
  • PS6K
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
SIZE: 525 amino acids; 59140 Da
SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Molecular Weight 64 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot in RIPA lysates from HEK293, PC-12,and A431 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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