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Milli-Mark™ Anti-Ras-FITC clone RAS10

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货号：FCMAB148F

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M FITC Monoclonal Antibody
Description
Catalogue Number FCMAB148F
Description Anti-Ras -FITC Antibody, clone RAS10
Alternate Names
  • GTP- and GDP-binding peptide B
    GTPase Hras
    Ha-Ras1 proto-oncoprotein
    Ras family small GTP binding protein H-Ras
    Transforming protein p2
    c-has/bas p21 protein
    c-ras-Ki-2 activated oncogene
    p19 H-RasIDX protein
    transformation gene: oncogene HAMSV
    v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Background Information The tumor oncoproteins HRas, KRas, and NRas are rated as Ras protoncogenes. Point mutations within Ras genes are frequently detected in human malignancies and in experimentally induced tumors in animals.
References
Product Information
Format FITC
Control
  • MCF-7 cells.
Presentation Purified mouse monoclonal IgG2aκ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Applications
Application Anti-Ras -FITC Antibody, clone RAS10 is an antibody against Ras for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Purified recombinant Ras.
Clone RAS10
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes p21H-, K- and N-Ras.
Isotype IgG2a
Species Reactivity
  • Human
Species Reactivity Note Tested and passed on Human. Unconjugated antibody (05-519) is known to react to Rat and Mouse.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]
Gene Symbol
  • K-Ras
  • Ki-Ras
  • K-Ras2
  • Kras-2
  • p21B
  • KRAS
  • RASK2
  • HRAS
  • HA_RAS
  • N-RAS
  • H-RAS
  • NRAS
  • NRAS1
  • ALPS4
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

SIZE: 189 amino acids; 21,656 Da

SUBUNIT: Interacts with PHLPP (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side.

Involvement in disease:

Defects in KRAS are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.


Defects in KRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.


Defects in KRAS are the cause of Noonan syndrome 3 (NS3) [MIM:609942]. Noonan syndrome (NS) [MIM:163950] is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS3 inheritance is autosomal dominant.


Defects in KRAS are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.


KRAS mutations are involved in cancer development
Molecular Weight ~21 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using MCF-7 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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