Anti-phospho-PRAS40 (Thr246) (rabbit polyclonal) - 炼石商城

您好！欢迎来到炼石商城请登录注册兼职小伙伴

我的购物车

0

Qiagen 凯杰 Biosharp Omega

全部商品分类

小伙伴店铺

客服热线 0771-3293894

首页抗体Millipore 密理博>

图片仅供参考，请以实物为准

收藏

Anti-phospho-PRAS40 (Thr246) (rabbit polyclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：07-1282

品牌：Millipore 密理博

配送至：

北京朝阳

支付：账期货到付款

数量：

EA (预计3-5工作日到货)

亲，想了解价格请QQ咨询客服！

工作时间

周一至周五：9:00-18:00

咨询电话

0771-3293894

在线咨询

: 客服郭恒蔡玉坤曾宪飞技术咨询

浏览了该商品的用户最终购买

RNeasy Mini Kit (50) 50次

RNeasy Mini Kit (50) 50次

3720.00

Plasmid Mini Kit I(200) 200次

Plasmid Mini Kit I(200) 200...

576.00

10ul吸头，透明，袋装，可灭菌 1000支/袋，50袋/箱

10ul吸头，透明，袋装，可灭菌...

85.80

浏览了该商品的用户还浏览了

QIAfilter Plasmid Maxi Kit (10) -10

QIAfilter Plasmid Maxi Kit (...

3000.00

QIAamp DNA Blood Midi Kit (20) 20次

QIAamp DNA Blood Midi Kit (2...

2680.00

QIAamp UCP Pathogen Mini Kit (50)

QIAamp UCP Pathogen Mini Kit...

4112.00

商品介绍
商品咨询

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, R, H, B	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	07-1282
Description	Anti-phospho-PRAS40 (Thr246) Antibody
Alternate Names	40 kDa proline-rich AKT substrate AKT1 substrate 1 (proline-rich) proline-rich Akt substrate, 40 kDa
Background Information	PRAS40 (Proline Rich Akt Substrate, 40kDa), also known as AKT1S1, is a ubiquitously express protein that is phosphorylated on residue Thr246 via the PI3K/Akt pathway. It was originally discovered as an Akt substrate as it has the putative Akt phosphorylation motif. This phosphorylation allows it to bind 14-3-3 and Raptor of the mTOR complex mTORC1. PRAS40 is known to bind to and regulate mTORC1 (mTOR, Raptor, mLST8) kinases activity that is activated by insulin downstream of PI3K and Akt and subsequently phosphorylates p70S6K and 4EBP1. PRAS40 is known to have a putative TOS motif (FVMDE) that allows it bind to Raptor of mTORC1. It is thought that through its binding to the Raptor, PRAS40 inhibits the kinase activity of mTORC1 by preventing to bind to its substrates such as p70S6K and 4EBP1.

References

Product Information
Format	Affinity Purified
Presentation	Antigen affinity purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Applications
Application	Anti-phospho-PRAS40 (Thr246) Antibody is an antibody against phospho-PRAS40 (Thr246) for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated synthetic linear peptide corresponding to the amino acids surrounding and including phosphorylated Thr246 of human PRAS40.
Epitope	Phosphorylated Thr246
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Detects PRAS40 when phosphorylated on Thr246.
Species Reactivity	Mouse Rat Human Bovine
Species Reactivity Note	Rat and Mouse. Predicted to cross-react with human and bovine based sequence homology of immunizing peptide.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_026270.3
Gene Symbol	Lobe MGC2865 PRAS40
Modifications	Phosphorylation
Purification Method	Affinity Purfied
UniProt Number	Q96B36
UniProt Summary	FUNCTION: May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection. SUBUNIT STRUCTURE: The phosphorylated form interacts with 14-3-3. SUBCELLULAR LOCATION: Cytoplasm › cytosolBy similarity. Note= Found in the cytosolic fraction of the brain By similarity. TISSUE SPECIFICITY: Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293).
Molecular Weight	40 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by western blot on untreated and Insulin-treated NIH/3T3 cell lysate Western Blot Analysis: 1:2,000 dilution of this antibody was used to detect PRAS40 in Insulin-treated NIH/3T3 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

登录 / 注册

购物指南免费注册批量采购购物流程购物保障

配送方式上门自提第三方配送炼石配送

支付方式货到付款账期付款

售后服务售后政策退款说明售后流程免责条款

服务热线

0771-3293894