Deruxtecan analog 1mg

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商品介绍
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Deruxtecan analog 是连接桥与药物的偶联物，是抗体-药物偶联物 (ADC) 的一部分。详细信息请参考专利文献 WO2017002776A1 中的化合物 1。

Description

Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC) extracted from patent WO2017002776A1, compound 1.

IC₅₀ & Target

Drug-linker conjugates for ADC^[1]

In Vitro

Antibody-drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window^[2].

Solvent & Solubility

In Vitro:

10 mM in DMSO

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9671 mL	4.8354 mL	9.6707 mL
5 mM	0.1934 mL	0.9671 mL	1.9341 mL
10 mM	0.0967 mL	0.4835 mL	0.9671 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. NOGUCHI, Shigeru, et al. METHOD FOR SELECTIVELY MANUFACTURING ANTIBODY-DRUG CONJUGATE. WO2017002776A1.

[2]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.

Molecular Weight	1034.05
Formula	C₅₂H₅₆FN₉O₁₃
CAS No.	1599440-13-7
SMILES	O=C(-;@C=;@C-;@C-;@1=O)-;@N1CCCCCC(NCC(NCC(N[C@@H](CC2=;@C-;@C=;@C-;@C=;@C-;@2)C(NCC(NCOCC(N[C@@H]3-;@C4=;@C5-;@C(-;@C(-;@N-;@6-;@C-;@5)=;@C-;@C(-;@[C@](O)(-;@C(-;@O-;@C-;@7)=O)CC)=;@C7-;@C6=O)=;@N-;@C8=;@C-;@C(F)=;@C(C)-;@C(-;@C-;@C-;@3)=;@C-;@4-;@8)=O)=O)=O)=O)=O)=O
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere