MC-Val-Cit-PAB 纯度:99.56% 5g

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首页酶、辅酶及抑制剂MCE>

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MC-Val-Cit-PAB 纯度:99.56% 5g

市场价：: 0.00

促销价：: ¥0.00

货号：HY-78738

品牌：MCE

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北京朝阳

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商品介绍
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MC-Val-Cit-PAB是可被组织蛋白酶切割的ADC连接桥，用于制备抗体-药物偶联物。美国FDA批准的药物，如布伦替卡韦，血清素使用了该连接桥。

Description

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.

IC₅₀ & Target

ADC linker^[1]

Solvent & Solubility

In Vitro:

DMSO : ≥ 22 mg/mL (38.42 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7463 mL	8.7313 mL	17.4627 mL
5 mM	0.3493 mL	1.7463 mL	3.4925 mL
10 mM	0.1746 mL	0.8731 mL	1.7463 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

Molecular Weight	572.65
Formula	C₂₈H₄₀N₆O₇
CAS No.	159857-80-4
SMILES	CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)NC(CCCCCN2C(C=CC2=O)=O)=O
Storage	4°C, stored under nitrogen
Shipping	Room temperature in continental US; may vary elsewhere